GHOST is a research project that addresses the field of primary hemostasis which is the first phase involved in stopping bleeding through the breach of a small vessel. An abnormality of primary hemostasis, predisposing to bleeding may be due to thrombocytopenia, a defect in platelet function, a deficiency in von Willebrand factor (vWF), which requires laboratory tests. These tests are important in the event of bleeding, before an intervention at risk of bleeding or when deciding on a treatment. Currently existing devices suffer from a lack of reliability and a lack of relevance, as the conditions are too different from in vivo conditions.

The objective of the project is to develop an integrated analysis system in whole blood and in flow coupling on the one hand a microfluidic cell reproducing the rheological conditions of a blood vessel, covered with a bio-interface on the surface and on the other hand, one or more devices allowing the detection and quantification of surface-platelet interactions. The device by real-time monitoring will assess each step of the primary hemostasis process.

This project is held by FEMTO-ST (T Leblois and is supported by the Bourgogne Franche-Comté region and the National Research Agency (ANR):

One Post-Doc has been recruited for this project.